How does arsenite poisoning work?
Answer: It will block pyruvate dehydrogenase complex in dihydrolipoamide stage.
How does arsenite poisoning work?
Answer: It will block pyruvate dehydrogenase complex in dihydrolipoamide stage.
Showing posts with label Pre TCA. Show all posts
Showing posts with label Pre TCA. Show all posts
Answer: It will block pyruvate dehydrogenase complex in dihydrolipoamide stage.
What are the 2 mechanisms that regulate the pyruvate dehydrogenase complex?
What are the 2 mechanisms that regulate the pyruvate dehydrogenase complex?
Answer:
1: E1 --> kinase associated with complex phosphorylates and inactivates E1, activated by phosphatase
2: energy charge --> ATP, acetyl CoA, and NADH inhibit the complex, stimulated by ADP and pyruvate
What characteristic allows lipoaminde to move between different active sites?
What characteristic allows lipoaminde to move between different active sites?
Answer: flexible linkages (lipoamide arm)
Which reaction is the rate-limiting step in the synthesis of acetyl CoA?
Which reaction is the rate-limiting step in the synthesis of acetyl CoA?
Answer: decarboxylation
What are the 5 coenzymes required for the synthesis of acetyl CoA?
What are the 5 coenzymes required for the synthesis of acetyl CoA?
Answer: thiamine pyrophosphate (TPP), lipoid acid, flavin adenine dinucleotide (FAD), CoA, and NAD+
What are the 3 steps of synthesis of acetyl CoA from pyruvate?
What are the 3 steps of synthesis of acetyl CoA from pyruvate?
Answer: decarboxylation (E1), oxidation (E1 and E2), and transfer to CoA (E2)
What is the importance of the decarboxylation of pyruvate reaction?
What is the importance of the decarboxylation of pyruvate reaction?
Answer: irreversible link between glycolysis and the citric acid cycle (CAC).
What enzyme forms acetyl CoA from pyruvate?
What enzyme forms acetyl CoA from pyruvate?
Answer: pyruvate dehyrdogenase- oxidatively decarboxylates pyruvate to form acetyl CoA.
What happens to pyruvate in anaerobic vs. aerobic conditions?
What happens to pyruvate in anaerobic vs. aerobic conditions?
Answer:
anaerobic: converted to lactic acid or ethanol
aerobic: converted to acetyl CoA to enter CAC
How many proteins are used to make sure pyruvate gets converted into acetyl CoA?
How many proteins are used to make sure pyruvate gets converted into acetyl CoA?
Answer: ~60
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