Clearance (CL) of a drug is defined as which of the following?
A) The fraction of drug dose reaching the systemic circulation following administration by any route
B) The time required for an amount of drug in blood to decline to one-half its measured value
C) A measure of the apparent space the body has available to contain the drug
D) The rate of elimination by all routes normalized to the concentration of drug, in some biological fluids
Answer: The rate of elimination by all routes normalized to the concentration of drug, in some biological fluids