The Friedewald formula for estimating LDL cholesterol should NOT be used when:
A) HDL cholesterol is greater than 40 mg/dL
B) Total cholesterol is elevated based on the age and sex of the patient
C) Plasma shows no visible evidence of lipemia
D) Triglyceride is greater than 400 mg/dL
Answer: Triglyceride is greater than 400 mg/dL