Explain the role of dynein in flagella movement.

Explain the role of dynein in flagella movement.

Answer: Dynein arms reach up to grab adjacent microtubule in doublet. Creates a bending that is used for motion.

What are focal contacts?

What are focal contacts?

Answer: The "feet" involved in cell crawling. This happens if a whole cell needs to move to a diff region. The focal contacts (contain integrin) form as actin polymerizes on the plus end. There is a contraction on the neg end as focal contacts are lost.

Why can drugs that affect microtubules and actin filaments be used for chemotherapy?

Why can drugs that affect microtubules and actin filaments be used for chemotherapy?

Answer: Tumor cells are rapidly dividing hence is their microfilament development (which is vital for cytokineses) is interfered with, they cannot divide properly

What is the structure of an Intermediate Filament like and why are they important in determining tumor metastasis?

What is the structure of an Intermediate Filament like and why are they important in determining tumor metastasis?

Answer: Made up of a series of very long monomers joined into teramers. They have N term and C term ends. They are specific to cell type and mark cell lineage so if found elsewhere, indicate metastasis.