What happens with insulin in type 2 diabetes?

What happens with insulin in type 2 diabetes?

Answer: insulin fails to inhibit gluconeogenesis by failing to shut down transcription of gluconeogenesis genes

Which activity of the bifunctional enzyme is determined by blood glucose levels?

Which activity of the bifunctional enzyme is determined by blood glucose levels?

Answer: single serine

What enzyme regulates the rates of glycolysis and gluconeogenesis in the liver to maintain blood glucose levels?

What enzyme regulates the rates of glycolysis and gluconeogenesis in the liver to maintain blood glucose levels?

Answer: key regulator of glucose metabolism is fructose 2,6-bisphosphate

How are glycolysis and gluconeogenesis reciprocally regulated?

How are glycolysis and gluconeogenesis reciprocally regulated?

Answer:


interconversion of phosphoenolpyruvate and pyruvate,
if ATP is required-glycolysis predominates
if glucose is required-gluconeogenesis is favored

What is a key regulatory site of glycolysis and gluconeogenesis?

What is a key regulatory site of glycolysis and gluconeogenesis?

Answer: interconversion of fructose 1,6-bisphosphate and fructose 6-phosphate

What determines whether glycolysis to gluconeogenesis will be most active?

What determines whether glycolysis to gluconeogenesis will be most active?

Answer: energy charge